Several episodes of Mythbusters featured attempts to validate or disprove scenes from Breaking Bad, often with Gilligan guest-starring in the episode to participate. In 2013, two scenes from the first season of Breaking Bad were put under scrutiny in a Mythbusters Breaking Bad special. Despite several modifications to what was seen in the show, both the scenes depicted in the show were shown to be physically impossible.[55] It was shown impossible to use hydrofluoric acid to fully dissolve metal, flesh, or ceramic as shown in the episode "Cat's in the Bag...", and that while it was possible to throw fulminated mercury against the floor to cause an explosion, as in the episode "Crazy Handful of Nothin'", Walter would have needed a much larger quantity of the compound and thrown at a much faster speed, and likely would have killed all in the room.[56][57] A later Mythbusters episode, "Blow It Out of the Water", tested the possibility of mounting an automated machine gun in a car as in the series finale "Felina", and found it plausible.[58] An episode of MythBusters Jr. proved that it was impossible for an electromagnet to draw metallic objects from across a room as in the episode "Live Free or Die".[59]
Jason Wallach of Vice magazine commended the accuracy of the cooking methods presented in the series. In early episodes, a once-common clandestine method, the Nagai red phosphorus/iodine method, is depicted, which uses pseudoephedrine as a precursor to d-(+)-methamphetamine.[60] By the season 1 finale, Walt chooses to use a different synthetic route based on the difficulty of acquiring enough pseudoephedrine to produce on the larger scale required. The new method Walt chooses is a reductive amination reaction, relying on phenyl-2-propanone and methylamine. On the show, the phenyl-2-propanone (otherwise known as phenylacetone or P2P) is produced from phenylacetic acid and acetic acid using a tube furnace and thorium dioxide (ThO2) as a catalyst, as mentioned in episodes "A No Rough-Stuff-Type Deal" and "Más". P2P and methylamine form an imine intermediate; reduction of this P2P-methylamine imine intermediate is performed using mercury aluminum amalgam, as shown in several episodes, including "Hazard Pay".[61]